Last updated:01.05.2015

Name of the Lecture:The Mechanisms of Cell Death, Apoptosis, and Autophagy

Required Prior Knowledge:

Aim of the Lecture:

Goals of the lecture:

Lecture Outlines:

  • Analogy for necrosis and apoptosis

  • Differences between necrosis and apoptosis

    • Morphologic features of necrosis and steps of necrosis development

    • Morphologic features of apoptosis and steps of apoptosis development

  • Necrosis

    • Nuclear changes in necrosis

      • Pyknosis

      • Karyolysis

      • Karyorrhexis

    • Necrosis, morphology, its effect to regional tissue and its removal
  • Apoptosis

    • Factors controlling apoptosis

    • Physiologic Causes of Apoptosis

    • Pathologic Causes of Apoptosis

    • Mechanisms of apoptosis

      • The Mitochondrial (Intrinsic) Pathway of Apoptosis

      • The Death Receptor (Extrinsic) Pathway of Apoptosis

      • Caspases

      • Clearance of Apoptotic Cells

    • Examples of Apoptosis
  • Necroptosis

  • Pyroptosis

  • Autophagy


  1. Robbins Basic Pathology, 9th edition

  2. Robbins and Cotran Pathologic Basis of Disease, 9th edition

  3. Programmed cell death:

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