Last updated:01.05.2015

Name of the Lecture:Intracellular Accumulations and Cellular Aging

Required Prior Knowledge:

Basic knowledge of intracellular transport

Basic knowledge about enzyme functions and metabolic pathways

Aim of the Lecture:

Goals of the lecture:

Lecture Outlines:

  • Intracellular accumulations

  • Intracellular accumulation mechanisms

    • Abnormal removal, inadequate transport

    • Abnormal folding, or depot

    • Abnormal anabolism, enzyme deficiency, byproducts

    • Exogenous materials that cannot be ingested

  • Fat accumulation

  • Protein accumulation

  • Glycogen accumulation

  • Pigments

    • Carbon

    • Lipofuscin

    • Melanin

    • Hemosiderin

    • Amyloid

    • Hyaline change

  • Pathologic Calcification

    • Dystrophic calcification

    • Metastatic calcification

    • Causes of hypercalcemia

  • Cellular aging

  • Why do we age?

  • DNA damage

  • Decreased cellular replication

  • Telomeres

  • Werner syndrome

References:

  1. Robbins Basic Pathology, 9th edition

  2. Robbins and Cotran Pathologic Basis of Disease, 9th edition

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